王晓泉，博士，现为兽医学院教授，硕士研究生导师。

研究方向：

1. 禽流感病毒流行病学调查和禽流感新型新型疫苗的开发。

2. 禽流感病毒适应性和水平传播机制和跨种传播机制研究。

科研项目：

1. 国家重点研发计划子课题（2021YFD1800202），2021-2025, 275万，主持。

2. 国家自然科学基金面上项目（31772755），2018-2021, 59万，主持。

3. 国家自然科学基金青年基金（31101827），2012-2014, 24万，主持。

4. 国家公益行业专项（ 201003012），2010-2014,110万，主持。

研究成果：

近五年来以第一或通讯作者（含共同）身份在《Lancet Microbe》，《Emerging Microbes & Infections》，《SCIENCE CHINA-Life Sciences》，《Journal of Infection》，《Virologica Sinica》，《Veterinary Microbiology》，《Journal of Virology》，《mBio》，《中国家禽》等杂志发表学术论文100余篇，其中第一作者或通讯作者SCI论文18篇，总影响因子 > 160。

[1]      Wang Xiaoquan#, Yu Huiyan#, Ma Yahao, Zhang Pinghu, Wang Xiyue, Liang Jianyu, Zhang Xiulian, Gao Ruyi, Lu Xiaolong, Yang Wenhao, Chen Yu, Gu Min, Hu Jiao, Liu Xiaowen, Hu Shunlin, Peng Daxin, Qi Xian, Bao, Changjun, Liu Kaituo, Liu Xiufan.  (2024) The novel H10N3 avian influenza virus acquired airborne transmission among chickens: an increasing threat to public health. mBio, e0236324(一区，IF: 5.1，第一作者)

[2]      Liu Kaituo, Qi Xian, Bao, Changjun^#, Wang Xiaoquan^# &Liu Xiufan. (2024) Novel H10N3 avian influenza viruses: a potential threat to public health. Lancet Microbe 5, e417 (一区，IF: 20.9，通讯作者)

[3]      Lu Xiaolong, Wang Xiaoquan, Liu Xiaowen &Liu Xiufan. (2024) The multifaceted interactions between Newcastle disease virus proteins and host proteins: a systematic review. Virulence 15, 2299182 (一区，IF：5.5)

[4]      Wang Xiaoquan^#, Cai Miao^#, Lu Xiaolong, Xu Qianqian, Wang Yanhong, Yang Wenhao, Liu Kaituo, Gao Ruyi, Chen Yu, Hu Jiao, Gu Min, Hu Shunlin, Liu Xiufan and Liu Xiaowen (2024) Research note: Simultaneous detection of GPV, H5 AIV, and GoAstV via TaqMan probe-based multiplex qPCR. Poult Sci 103, 104511 (一区，IF：3.8，第一作者)

[5]      Wang Xiaoquan^#, Lu Xiaolong^#, Wang Mingzhu^#, Zhou Qiwen, Wang Xiyue, Yang Wenhao, , Liu Kaituo, Gao Ruyi, Liao Tianxing, Chen Yu, Hu Jiao, Gu Min, Hu Shunlin, Liu Xiufan and Liu Xiaowen. (2024) RNA-Seq Profiling in Chicken Spleen and Thymus Infected with Newcastle Disease Virus of Varying Virulence. Vet Sci 11 (二区，IF：2.0，第一作者)

[6]      Wang Xiaoquan^#, YAO Yao^#, Yang Wenhao, Lu Xiaolong, Gao Ruyi, LIU KAITUO, Chen Yu, GU, MIN, HU, JIAO, HU, SHUNLIN ,Liu Xiaowen. &Liu Xiufan. (2024) Development and Evaluation of a Novel Chimeric Genotype VII Newcastle Disease Vaccine: Overcoming Maternal Antibody Interference and Spray Administration. Vet Sci 11  (二区，IF：2.0，第一作者)

[7]      Yang Wenhao, ZHANG, J., DAI JING, GUO, M., LU XIAOLONG, GAO, RUYI, LIU KAITUO, GU, MIN, HU, SHUNLIN ,Liu Xiaowen, Wang Xiaoquan* &Liu Xiufan*. (2024) Multiple pathways to evaluate the immunoprotective effect of Turkeys Herpesvirus recombinant vaccine expressing HA of H9N2. Poult Sci 104, 104335 (一区，IF：3.8，通讯作者)

[8]      Yuling Sun, Lei Ji, Wei Liu, Jing Sun, Penggang Liu, Xiaoquan Wang, Xiufan Liu and Xiulong Xu (2024) Influenza A virus infection activates caspase-8 to enhance innate antiviral immunity by cleaving CYLD and blocking TAK1 and RIG-I deubiquitination. Cell Mol Life Sci 81, 355  (一区，IF：8)

[9]      Jingting Zhan1, Yunhan Wu, Yujie Wang, Penggang Liu, Kaituo Liu, Jing Sun, Pinghu Zhang, Xiaoquan Wang, Xiufan Liu, Xiulong Xu (2024) Influenza A virus infection activates STAT3 to enhance SREBP2 expression, cholesterol biosynthesis, and virus replication. iScience 27, 110424 (一区，IF：4.8)

[10]   Xu Naiqing, Tang Xinen, Wang Xiyue, Cai Miao, Liu Xiufan, Lu Xiaolong, Hu Shunlin, Gu Min, Hu Jiao,  Gao Ruyi,  Liu Kaituo,  Chen Yu,  Liu Xiufan*, Wang Xiaoquan* (2024) Hemagglutinin affects replication, stability and airborne transmission of the H9N2 subtype avian influenza virus. Virology 589, 109926(三区，IF: 3.7，通讯作者）

[11]   Yang Wenhao, Liu Xiufan. & Wang Xiaoquan* (2023) The immune system of chicken and its response to H9N2 avian influenza virus. Vet Q 43, 1-14  (二区，IF: 6.4，通讯作者）

[12]   Xu Naiqing, Wang Xiyue, Cai Miao, Tang Xinen, Yang Wenhao, Lu Xiaolong, Liu Xiaowen, Hu Shunlin, Gu Min, Hu Jiao,  Gao Ruyi,  Liu Kaituo,  Chen Yu,  Liu Xiufan*, Wang Xiaoquan* (2023) Mutations in HA and PA affect the transmissibility of H7N9 avian influenza virus in chickens. Vet Microbiol 287, 109910  (二区，IF: 3.3，通讯作者)

[13]   Wang Xiaoquan^#, Zheng Huafeng^#, Gao Ruyi, Ren Leyao, Jin Mingxia, Ji Zhuxing, Wang Xiyue, Lu Xiaolong, Yang Wenhao, Gu Min, Liu Xiaowen, Hu Shunlin,  Liu Kaituo,  Liu Xiufan* (2023) Genetically Related Avian Influenza H7N9 Viruses Exhibit Different Pathogenicity in Mice. Animals (Basel) 13 (二区，IF: 3.2，第一作者)

[14]   Wang Xiyue, Liu Kaituo, Pei Yuru, Chen Xia, Lu Xiaolong, Lu Xiaolong, Gao Ruyi, Chen Yu, Gu Min, Hu Jiao, Liu Xiaowen, Hu Shunlin,   Jiao Xinan,  Liu Xiufan*, Wang Xiaoquan* (2023) Emergence of a new designated clade 16 with significant antigenic drift in hemagglutinin gene of H9N2 subtype avian influenza virus in eastern China. Emerg Microbes Infect 12, 2249558 (二区，IF: 13.2，共同通讯作者)

[15]   Liu Kaituo, Guo Yaqian, Zheng Huafeng, Ji ZhuXing, Cai Miao, Gao Ruyi, Zhang Pinghu, Liu Xiaowen, Xu Xiulong, Wang Xiaoquan* &Liu Xiufan*. (2023) Enhanced pathogenicity and transmissibility of H9N2 avian influenza virus in mammals by hemagglutinin mutations combined with PB2-627K. Virol Sin 38, 47-55 (二区，IF: 5.5，共同通讯作者)

[16]   Zhang Libing^#, Liu Kaituo^#, Su Qin^#, Chen Xiao^#, Wang Xiaoquan^#, Li Qingfeng, Wang Wenlei, Mao Xuhua, Xu Jinmei, Zhou Xin, Xu Qin, Zhou Le, Liu Xiufan, Zhang Pinghu. (2022) Clinical features of the first critical case of acute encephalitis caused by the avian influenza A (H5N6) virus. Emerg Microbes Infect 11, 2437-2446 (二区，IF: 13.2，共同第一作者)

[17]   Yang Wenhao, Dai Jing, Liu Jingjing, Guo Mengjiao, Liu Xiaowen, Hu Shunlin, Gu Min, Hu Jiao, Hu Zenglei, Gao Ruyi, Liu Kaituo, Chen Yu, Liu Xiufan, Wang Xiaoquan*. (2022) Intranasal Immunization with a Recombinant Avian Paramyxovirus Serotypes 2 Vector-Based Vaccine Induces Protection against H9N2 Avian Influenza in Chicken. Viruses 14 (二区，IF: 5.8，通讯作者）

[18]   Liu Kaituo, Ding Pingyun, Pei Yuru, Gao Ruyi, Han Wenwen, Zheng Huafeng, Cai Miao, Gu Jinyuan, Li Xiuli, Gu Min, Hu Jiao, Liu Xiaowen, Hu Shunlin, Zhang Pinghu, Wang Xiaobo, Wang Xiaoquan*, Liu Xiufan*. (2022) Emergence of a novel reassortant avian influenza virus (H10N3) in Eastern China with high pathogenicity and respiratory droplet transmissibility to mammals. Sci China Life Sci 65, 1024-1035  (一区，IF: 9.1，共同通讯作者)

[19]   Liu Kaituo, WANG Xiaoquan, JIANG Daxiu, XU NAIQING, GAO RUYI, HAN Wenwen, GU MIN, HU JIAO, Liu Xiaowen, Hu Shunlin &Liu Xiufan*. (2021) Pathogenicity and transmissibility of an H9N2 avian influenza virus that naturally harbors the mammalian-adaptive molecular factors in the hemagglutinin and PB2 proteins. J Infect 82, e22-e23 （一区，IF：38）

[20]   Ji Zhuxing, Wang Xiaoquan &Liu Xiufan*. (2021) NS1: A Key Protein in the "Game" Between Influenza A Virus and Host in Innate Immunity. Front Cell Infect Microbiol 11, 670177  (二区，IF: 5.293）

[21]   Gao Ruyi, Zheng Huafeng, LIU KAITUO, JI, ZHUXIN, Cai Miao, GU MIN, Hu Jiao, Liu Xiaowen, Hu Shunlin, Wang Xiaoquan* &Liu Xiufan*. (2021) Genesis, evolution and host species distribution of influenza A (H10N3) virus in China. J Infect 83, 607-635 （一区，IF：38，共同通讯作者）

[22]   Wang Xiaoquan^#, ILYUSHINA, N. A., LUGOVTSEV, V. Y., BOVIN, N. V., COUZENS, L. K., GAO, J., DONNELLY, R. P., EICHELBERGER, M. C. & WAN, H. (2017) Amino Acids in Hemagglutinin Antigenic Site B Determine Antigenic and Receptor Binding Differences between A(H3N2)v and Ancestral Seasonal H3N2 Influenza Viruses. J Virol 91 (二区，IF:4.5, 第一作者）

[23]   ZHONG Lei, Wang Xiaoquan, LI Qi, LIU Dong, CHEN Hongzhi, ZHAO Mingjun, GU Xiaobing, HE Liang ,Liu Xiaowen, GU Min, PENG Daxin. &Liu Xiufan. (2014) Molecular mechanism of the airborne transmissibility of H9N2 avian influenza A viruses in chickens. J Virol 88, 9568-9578 (二区，IF:4.5）

    科研奖励：

1. 江苏省科学技术奖二等奖，2022, 第九完成人；

2. 国家技术发明奖二等奖，2020，第四完成人；

3. 教育部科技进步一等奖，2016，第五完成人。
   

团队名称：传染病学科研团队

团队介绍：该团队在刘秀梵院士领导下主要进行家禽传染病的流行病学、病原学、致病机制和防控方面的研究。