个人简介：  

       李晨曦，中共党员，博士，副教授，硕士生导师; 2010-2014年就读于吉林大学获理学学士学位;2014-2020年就读于中国农业科学院获农学博士学位。目前主要从事兽医微生物学与免疫学相关的教 学和科研工作，研究方向聚焦于蚊媒病毒-黄病毒（日本脑炎病毒JEV与坦布苏病毒TMUV）的致病机制、免疫应答机制及抗病毒药物筛选等方面的工作。主持包括国家自然科学基金，“十四五国家重点研 发计划”子课题等在内的项目共6项。获扬州大学高层次人才科研启动项目与扬州市“绿杨金凤”优秀博士项目资助。以第一作者或通讯作者在《Advanced Science》,《PLoS Pathogens》,《mBio》,《Journal of Immunology》,《Antiviral Research》等杂志发表SCI论文16篇，累计发表SCI论文40余篇(论文列表：https://www.ncbi.nlm.nih.gov/myncbi/collections/mybibliography/)。申请发明专利8项，授权发明专利4项。担任《Zoonoses》、《Animals and Zoonoses》期刊青年编委；担任《Emerging Microbes & Infections》，《Virology of Journal》等多个杂志审稿人。

         代表论著：

      (1) Chenxi Li, Chenyang Tang,Xiqian Liu, Ying Liu, Linjie Zhang,Jing Shi,Qingyu Li,Mingan Sun, Yanhua Li.E3 ubiquitin ligase MARCH5 positively regulates Japanese  encephalitis virus infection by catalyzing the K27-linked  polyubiquitination of viral E protein and inhibiting MAVS-mediated type I interferon production. mBio,2025,10.1128/mbio.00208-25.

      (2) Chenxi Li,Di Di,Hui Huang,Xin Wang,Qiqi Xia,Xiaochun Ma,Ke Liu,Donghua Shao,Yafeng Qiu,Zongjie Li,Beibei Li,Jianchao Wei.NS5-V372A and NS5-H386Y variations are responsible for differences in interferon α/β induction and co-contribute to the replication advantage of Japanese encephalitis virus genotype I over genotype III in ducklings.[SCI].PLoS Pathogens,2020,16(9)(e1008773).     

      (3) Chenxi Li, Linjie Zhang, Xuan Chen, Daoyuan Jiang, Jingbo Hu, Jinyao Guo, Jingjing Ding, Xue Jiao, Wenbin Bao, Yanhua Li. Evaluation of the genotype I Japanese encephalitis virus as a stable viral vector for foreign gene expression. ANTIVIRAL RESEARCH, 2023,175:106002.   

    (4) Chenxi Li ,Xuan Chen, Yanyangzhou,Jingbo Hu,Xinjie Wang, Yanhua Li.Novel reverse genetics of genotype I and III Japanese encephalitis viruses assembled through transformation associated recombination in yeast: The reporter viruses expressing a green fluorescent protein for the antiviral screening assay.ANTIVIRAL RESEARCH,2022,197.   

     (5) Chenxi Li, Linjie Zhang, Chenyang Tang, Xuan Chen, Jing Shi, Qingyu Li, Xue Jiao, Jinyao Guo, Bin Wang, Kefan Bu, Abdul Wahaab, Yuguo Yuan, Ming-An Sun, Yanhua Li. DDX3 Regulates the Cap-Independent Translation of the Japanese Encephalitis Virus via Its Interactions with PABP1 and the Untranslated Regions of the Viral Genome. Advanced Science (weinh). 2025 May 8:e2502493. 

    (6) Chenxi Li, Linjie Zhang, Chenyang Tang, Yanbing Zhang, Wen  Zhao. Isolation and identification of a duck-derived Japanese encephalitis virus and evaluation of its virulence in mice.Veterinary Microbiology. 2024 Mar;290:109976.

   (7) Chenxi Li,Yanyang Zhou,Xuan Chen,Yanbing Zhang,Jingbo Hu,Cicheng Ren,Jingjing Ding,Daoyuan Jiang.Porcine TRIM35 positively regulate TRAF3-mediated IFN-β production and inhibit Japanese encephalitis virus replication. Developmental & Comparative Immunology,2022,127:104290. 

   (8) Xueming Chen,Chenxi Li,Tongtong Li,Weiwei Lin,Xiaojun Li,Xiaofei Bai,Wulin Shaozhou,Qingshan Zhang,Shuang Li,Ming Liu,Jyung-Hurng Liu.A Novel Neutralizing Antibody Targeting a Unique Cross-Reactive Epitope on the hi Loop of Domain II of the Envelope Protein Protects Mice against Duck Tembusu Virus. Journal of Immunology,2022,204(7)(1836-1848（共同一作）.

  (9) Chenxi Li,Di Di,Xin Wang,Qiqi Xia,Abdul Wahaab,Muhammad Naveed Anwar,Zongjie Li,Donghua Shao,Ke Liu,Yafeng Qiu,Jianchao Wei,Beibei Li.Duck karyopherin α4 (duKPNA4) is involved in type I interferon expression and the antiviral response against Japanese encephalitis virus.Developmental & Comparative Immunology,2020,104:103535.

  (10) Changguang Xiao,Chenxi Li,Julien Cappelle,LiHong Liu,Linlin Pang,Xin Wang,Jinpeng Xu,Di Di,Ke Liu,Beibei Li,Donghua Shao,Yafeng Qiu,Weijie Ren,Frederik Widén,Véronique Chevalier,Jianchao Wei,Xiaodong Wu.Differential replication efficiencies between Japanese encephalitis virus genotype I and III in avian cultured cells and young domestic ducklings. PLoS Negl Trop Dis,2018,12(12)(e0007046).

      指导学生：

  （1）陈萱，2020级硕士研究生，发表SCI论文2篇、授权发明专利2项，毕业就业于默沙东（美国）动物保健中国研发及工艺技术中心；

  （2）张林杰，2022级硕士研究生，发表SCI论文3篇、授权发明专利1项，荣获硕士“国家奖学金”、“冯氏企业奖学金”，毕业就业于华淞（上海）生物医药科技股份有限公司；

  （3）唐晨阳，2023级硕士研究生，发表SCI论文1篇，2025年转博-硕博连读；

  （4）郭文壮，2024级硕士研究生，发表SCI论文1篇，硕士在读；

  （5）李静静，2024级硕士研究生，硕士在读；

   （6）刘莹，2021级本科生，发表SCI论文3篇，荣获“全国生命科学大赛”国赛一等奖（最高奖），本科在读；